Cardiothoracic & vascular anesthesia
Prospective, Randomized Study of Fibrinogen Concentrate Versus Cryoprecipitate for Correcting Hypofibrinogenemia in Cardiac Surgery Patients
Authors' conclusion
Analysis of plasma fibrinogen concentration showed that cryoprecipitate and FC had comparable effectiveness.
Study context
- Population
- Adults with clinically significant bleeding and acquired hypofibrinogenemia (<2.0 g/L) after cardiopulmonary bypass (CPB), Astana, Kazakhstan, 2021–2022
- Participants
- 88 adults
- Comparison
- Fibrinogen concentrate (FC) vs Cryoprecipitate
- FCn = 48
- Cryoprecipitaten = 40reference
- Primary endpoint
- Direct treatment cost
Methodological detailssingle-centre, prospective
- Single-centre
- Prospective
Primary result
As reported in the abstract
Direct cost of treatment per patient
Cryoprecipitate
$1,505.06
mean · SD $152.40 · per patient
FC
$631.75
mean · SD $223.67 · per patient
P < 0.0001
Secondary outcomes
Mean, mg/dL
| Outcome | Cryoprecipitate | FC |
|---|---|---|
| Increase in mean plasma fibrinogen from before administration · 24 hours after | 125 (SD 65) | 96 (SD 65) |
Fibrinogen levels · 48 hours after administration
- No significant difference in fibrinogen levels between groups
Original publication
Prospective, Randomized Study of Fibrinogen Concentrate Versus Cryoprecipitate for Correcting Hypofibrinogenemia in Cardiac Surgery Patients. J Cardiothorac Vasc Anesth. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →