Cardiothoracic & vascular anesthesia
Pulmonary Vasodilator and Inodilator Drugs in Cardiac Surgery: A Systematic Review With Bayesian Network Meta-Analysis
Authors' conclusion
Inhaled prostacyclin was the only pharmacologic intervention whose use is supported by a statistically discernible improvement in mortality in the perioperative cardiac surgery setting as treatment of pulmonary hypertension.
Study context
- Population
- Adults with pulmonary hypertension undergoing elective cardiac surgery (perioperative setting)
- Participants
- 1,879 adults · 28 studies
- Comparison
- Inodilators and pulmonary vasodilators vs placebo or standard care
- Outcome
- In-hospital mortality
Pooled result
As reported in the abstract
In-hospital mortality (10 studies, 855 patients, 12 interventions)
- Only inhaled prostacyclin showed a statistically discernible improvement in mortality
- Inhaled prostacyclin vs Placebo or standard care: CrI 1.26 × 10-17 - 0.7
- CrI
Further pooled results
ICU LOS
- Inhaled prostacyclin and nitric oxide associated with reduced ICU stay
Ventilation duration, stage 3 AKI, cardiogenic shock requiring mechanical support, change in mean pulmonary artery pressure
- No intervention reached a statistically evident difference vs usual care or placebo
Original publication
Pulmonary Vasodilator and Inodilator Drugs in Cardiac Surgery: A Systematic Review With Bayesian Network Meta-Analysis. J Cardiothorac Vasc Anesth. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →