ICU sedation, delirium & recovery
Quadriceps Muscle Layer Thickness and its association with frailty in critically ill patients: A prospective observational study
Main finding · QMLTResult — go to the resultOdds ratio 0.205 95 % CI 0.083–0.509Authors' conclusion
We found an independent association between Quadriceps Muscle Layer Thickness (QMLT) and frailty. QMLT decreased progressively with CFS scores. Frail patients with lower QMLT had increased 28-day mortality.
Study context
- Population
- Critically ill patients aged >65 years in an ICU in India
- Participants
- 120 patients
- Exposure
- Frail vs non-frail
- Outcome
- Association between QMLT (ultrasound at admission) and frailty (CFS)
Methodological detailssingle-centre
- Single-centre
Main finding
QMLT · admission
Odds ratio
0.205
95 % CI 0.083–0.509
P = 0.001
By group
Lower QMLT
OR 0.205 (95 % CI 0.083–0.509); P = 0.001
As reported in the abstract
- Quadriceps Muscle Layer Thickness (QMLT) decreased with increasing Clinical Frailty Scale (CFS)
- P < 0.001
Observational data: associations, not effects.
Further findings
Mortality
P = 0.022
Other factors independently associated with frailty
| OR (95 % CI) | P value | ||
|---|---|---|---|
| Increasing age | 1.14 (1.055–1.231) | P = 0.001 | |
| Higher APACHE II score | 1.078 (1.009–1.151) | P = 0.025 | |
| 0.512Odds ratio (log scale) |
28-day mortality by frailty and QMLT (median 1.96 cm)
- Frail with QMLT below median vs non-frail and frail with QMLT above median (as printed)
- 48.97 % vs. 16.12 % vs. 18.18 % vs. 17.24 %, p = 0.003
Original publication
Quadriceps Muscle Layer Thickness and its association with frailty in critically ill patients: A prospective observational study. J Crit Care. Published 19 October 2024. doi:10.
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