Cardiothoracic & vascular anesthesia
Quantification of exhaled propofol is not feasible during single‐lung ventilation using double‐lumen tubes: A multicenter prospective observational trial
Authors' conclusion
During single-lung ventilation, propofol concentration in exhaled air, in contrast to our expectations, increased by approximately one third.
Study context
- Population
- Patients scheduled for lung surgery under propofol and remifentanil anaesthesia with left-sided double-lumen tubes, 2 centres
- Participants
- 30 patients · 2 centres
- Exposure
- Single-lung vs double-lung ventilation via double-lumen tubes
- Outcome
- Exhaled propofol concentration normalized to plasma concentration
Methodological detailsmulticentre, in vitro step, Exhaled propofol measured at 1-min intervals; plasma propofol sampled every 20 min
- Multicentre
- In vitro step
- Exhaled propofol measured at 1-min intervals; plasma propofol sampled every 20 min
Main finding
As reported in the abstract
Normalized propofol exhalation during lung surgery
- 31% higher during single-lung vs double-lung ventilation
Observational data: associations, not effects.
Further findings
In-vitro propofol adhesion to double-lumen tubes
- Clamping bronchial lumen: more pronounced increase in propofol gas concentration (Δ AUC)
- +62%
- Ventilation of double-lumen tubes: increasing propofol concentrations at distal end over time
- In vitro
Original publication
Quantification of exhaled propofol is not feasible during single‐lung ventilation using double‐lumen tubes: A multicenter prospective observational trial. Acta Anaesthesiol Scand. Published 27 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →