Perioperative medicine & outcomes
Quantitative Electroencephalogram Changes before and after Postoperative Delirium: A Prospective, Multicenter Cohort Study
Main finding · Baseline beta amplitude-based connectivityResult — go to the resultβ −0.36Authors' conclusion
This study identified reduced preoperative beta amplitude-based connectivity as a possible marker of neurophysiological vulnerability for POD. However, the absence of significant longitudinal changes in quantitative EEG measures suggests that resting-state EEG networks may functionally recover or compensate in this cohort at 3 months postoperative.
Study context
- Population
- Patients aged 65 yr or older without preexistent cognitive dysfunction undergoing major elective surgery, and nonsurgical controls330 with sufficient EEG data
- Participants
- 379 patients
- Exposure
- Postoperative delirium (POD) vs Nonsurgical controls
- PODn = 59
- Nonsurgical controlsn = 57reference
- Outcome
- Quantitative EEG measures (relative power, phase- and amplitude-based functional connectivity, spectral variability, signal complexity) before and after surgery
- Follow-up
- 3 months after surgery
Methodological detailsmulticenter
- Multicenter
Main finding
Baseline beta amplitude-based connectivity · Baseline
β
−0.36
Pcorrected = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
- POD incidence
- 18% · 59
- POD incidence: of 330 with sufficient EEG data
Original publication
Quantitative Electroencephalogram Changes before and after Postoperative Delirium: A Prospective, Multicenter Cohort Study. Anesthesiology. Published 9 March 2026. doi:10.
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