Respiratory failure & ventilation
Racial and ethnic minority participants in clinical trials of acute respiratory distress syndrome
Authors' conclusion
Representation of racial and ethnic minority participants in ARDS trials from North America, published between 2000 and 2019, did not change over time. Black and Hispanic participants with ARDS may have similar mortality as White participants within trials.
Study context
- Population
- Participants with ARDS in ARDS Network and PETAL Network therapeutic trials published 2000–2019
- Participants
- 5,375 participants · 8 trials
- Comparison
- Racial and ethnic minority vs White participants
- Primary endpoint
- Temporal trends of representation and mortality of racial and ethnic minority participants
Methodological detailspooled trial data, temporal trend analysis
- Pooled trial data
- Temporal trend analysis
Primary result
As reported in the abstract
Representation of racial and ethnic minority participants
- Black, Hispanic, or Other race participants
- 1634 (30.4%)
- Representation did not change significantly over time
- p = 0.257
Further findings
Mortality, five most recent trials (n = 2923)
P = 0.633
Mortality difference, minority vs White, moderate to severe ARDS (PaO2/FiO2 < 150)
- Difference in mortality between minority and White participants decreased over time
Mortality, five most recent trials (n = 2923)
- No statistically significant differences in mortality between racial/ethnic groups, even after adjusting for potential confounders
Original publication
Racial and ethnic minority participants in clinical trials of acute respiratory distress syndrome. Intensive Care Med. Published 17 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →