A randomized controlled trial of the intraoperative use of noninvasive ventilation versus supplemental oxygen by face mask for procedural sedation in an electrophysiology laboratory
Primary resultResult — go to the resultRelative risk 1.29 95% CI 1.13–1.47Authors' conclusion
Respiratory events were more frequent among patients receiving NIV without any safety or outcome impairment.
Study context
- Population
- ASA Physical Status III or IV patients under sedation during electrophysiology laboratory procedures
- Participants
- 195 participants
- Comparison
- Noninvasive ventilation (NIV) vs face mask oxygen therapy during sedation
- NIVn = 98
- Face maskn = 97reference
- Primary endpoint
- Incidence of respiratory events: hypoxemia (SpO2 < 90%) or apnea/hypopnea (absence of breathing for 20 sec on capnography)
Methodological detailsblinded computer-driven outcome analysis
- Blinded computer-driven outcome analysis
Primary result
As reported in the abstract
Relative risk
1.29
95% CI 1.13–1.47
P < 0.001
Events by treatment group
NIV vs Face mask
RR 1.29 (95% CI 1.13–1.47); P < 0.001
Secondary outcomes
| Outcome | NIV | Face mask | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Hypoxemia | 42% | 34% | 1.21 (0.84–1.74) | P = 0.30 | |
| Apnea/hypopnea | 92% | 70% | 1.32 (1.14–1.53) | P < 0.001 | |
| 0.512Relative risk (log scale) |
Hemodynamic variables, sedation, patient outcomes
- Not different between the groups
Safety
Major or minor safety events
- Not different between the groups
Original publication
A randomized controlled trial of the intraoperative use of noninvasive ventilation versus supplemental oxygen by face mask for procedural sedation in an electrophysiology laboratory. Can J Anaesth. Published 2 June 2023. doi:10.
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