Pediatric anesthesia & critical care
Real‐World Impact on Postoperative Vomiting by Changing Anesthesia Regimens in Children Undergoing Strabismus Surgery: An Interrupted Time Series Analysis
Authors' conclusion
Real-world departmental-level data showed a decrease in POV occurrence after transitioning from sevoflurane-based anesthesia with pentazocine to propofol/opioid TIVA with DEX. However, no significant decrease in POV occurrence was found by adding OND to propofol/opioid TIVA with DEX.
Study context
- Population
- Children aged < 18 years undergoing strabismus surgery without major comorbidities, single tertiary-care children's hospital in Japan
- Participants
- 2,378 children
- Exposure
- Phase 1 vs Phase 2
- Phase 1n = 471reference
- Phase 2n = 1,260
- Phase 3n = 647
- Outcome
- POV or use of antiemetics
- Follow-up
- Within 24 h or by discharge
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Time-trend changes in postoperative vomiting (POV) occurrence
- No significant difference during Phases 2 and 3
Original publication
Real‐World Impact on Postoperative Vomiting by Changing Anesthesia Regimens in Children Undergoing Strabismus Surgery: An Interrupted Time Series Analysis. Paediatr Anaesth. Published 22 August 2025. doi:10.
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