Refractory septic shock and alternative wordings: A systematic review of literature
Authors' conclusion
Marked inconsistencies were identified in the usage of the terms for refractory septic shock.
Study context
- Population
- Studies reporting data on refractory septic shock, catecholamine resistance or high-dose norepinephrine
- Participants
- 562 participants · 8 studies
- Outcome
- Definitions used for refractory septic shock, catecholamine resistance and high-dose norepinephrine
Pooled result
As reported in the abstract
Definitions of terms
- Catecholamine resistance generally defined as decreased vascular responsiveness to catecholamine independently of the norepinephrine dose
- Refractory septic shock broadly defined as persistent hyperdynamic shock despite adequate fluid resuscitation and high-dose norepinephrine (≥ 1 μg/kg/min)
- Reported high doses of norepinephrine often ≥1 μg/kg/min
- Wide variability in the use of these terms
- 3 RCTs, 3 prospective and 2 retrospective studies
Original publication
Refractory septic shock and alternative wordings: A systematic review of literature. J Crit Care. Published 25 January 2023. doi:10.
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