Cardiac arrest & resuscitation
Regional Brain Net Water Uptake in Computed Tomography after Cardiac Arrest – A Novel Biomarker for Neuroprognostication
Authors' conclusion
This pilot study indicates that NWU derived from serial head CTs is a promising novel biomarker for outcome prediction after CA. NWU >8% in basal ganglia grey matter regions predicted poor outcome while absence of NWU indicated good outcome.
Study context
- Population
- Patients after OHCA or in-hospital cardiac arrest81 derivation, 34 validation
- Participants
- 115 patients
- Outcome
- Poor neurological outcome:
- CPC in derivation
- Modified Rankin Scale (mRS) in validation cohort
Methodological detailsobservational prognostic accuracy study, derivation (single-centre registry) and validation (international multicentre TTM2 trial) cohorts, pilot study
- Observational prognostic accuracy study
- Derivation (single-centre registry) and validation (international multicentre TTM2 trial) cohorts
- Pilot study
Performance
As reported in the abstract
Prediction of poor outcome
| Test or model | Specificity | Sensitivity |
|---|---|---|
| Net water uptake (NWU) >8% in putamen and caudate nucleus | 100% (95%-CI: 86-100%) | 43% (95%-CI: 31-56%) |
Net water uptake (NWU) >8% in putamen and caudate nucleus
Specificity100% (95%-CI: 86-100%)
Sensitivity43% (95%-CI: 31-56%)
Original publication
Regional Brain Net Water Uptake in Computed Tomography after Cardiac Arrest – A Novel Biomarker for Neuroprognostication. Resuscitation. Published 23 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →