Hemodynamics, fluids & transfusion
Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study
Authors' conclusion
The continuing decline of CVR below the LLCA indicated that brain vasculature is still able to react on changing BP.
Study context
- Population
- Patients undergoing off-pump aortic root aneurysm surgery with sustained intraoperative hypotension
- Participants
- 50 patients
- Exposure
- Cerebrovascular resistance (CVR) and systemic vascular resistance (SVR) changes above vs below the individual lower limit of cerebral autoregulation (LLCA) during induced hypotension
- Outcome
- CVR and SVR change per 10 mm Hg decrease in MAP, above and below the LLCA
Main finding
As reported in the abstract
- LLCA (mean (SD))
- 58 (12) mm Hg
- MCAVmean at LLCA
- 32 (8) cm s-1
- Cardiac output (CO) at LLCA
- 5.1 (1.2) L min-1
- Above LLCA: decline in CVR and SVR, each per 10 mm Hg decrease in MAP (P<0.001)
- 19%
- Below LLCA: decline in CVR per 10 mm Hg decrease in MAP (P<0.001)
- 7%
- Below LLCA: decrease in SVR per 10 mm Hg decrease in MAP (P<0.001)
- 13%
Observational data: associations, not effects.
Original publication
Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study. Br J Anaesth. Published 28 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →