Pediatric anesthesia & critical care
Relationship between decrement time and recovery time in pediatric total intravenous anesthesia with propofol and remifentanil
Authors' conclusion
There was variation between decrement time to 1.5 μg.mL-1 and recovery time of over 5 min in nearly half of patients.
Study context
- Population
- Children anesthetised with propofol-remifentanil total intravenous anesthesia (TIVA) for a variety of surgical procedures, Birmingham Children's Hospitalaudited
- Participants
- 55 children
- Exposure
- Pump-estimated decrement time to 1.5 μg.mL-1 vs recovery time
- Outcome
- Agreement/correlation between decrement time (to 1.5 μg.mL-1) and recovery time (eye opening)
Methodological detailsobservational study, single-centre, Median age 7.2 years (range 0.9-15.9); median weight 26 kg (range 8.5-77)
- Observational study
- Single-centre
- Median age 7.2 years (range 0.9-15.9); median weight 26 kg (range 8.5-77)
Main finding
As reported in the abstract
Decrement time vs recovery time
- Median decrement time (IQR 8.3-21)
- 11.8 min
- Median recovery time (IQR 9-20)
- 15 min
- Recovery time same as decrement time
- 2%
- Recovery time less than decrement time
- 40%
- Recovery time more than decrement time
- 58%
- Median absolute deviation of difference between decrement and recovery time (from a median of 1 min)
- 5.7 min
Observational data: associations, not effects.
Further findings
Estimated plasma propofol concentration at eye opening
- Two thirds of patients opened eyes at estimated concentration between 1.2 and 1.8 μg.mL-1
Original publication
Relationship between decrement time and recovery time in pediatric total intravenous anesthesia with propofol and remifentanil. Paediatr Anaesth. Published 30 March 2023. doi:10.
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