Pediatric anesthesia & critical care
The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study)
Authors' conclusion
Keeping TIVA within the recommended BIS mean (range) of 40 to 60 (35-65) did not affect TcMEP reproducibility or surgeons' interpretation of TcMEP.
Study context
- Population
- Youths undergoing total intravenous anesthesia (TIVA) (propofol and remifentanil) for scoliosis surgery with surgeon-directed transcranial motor evoked potentials (TcMEP)
- Participants
- 150 participants
- Exposure
- Deeper TIVA vs initial TIVA
- Outcome
- Effect of anesthesia depth (BIS60 vs BIS40) on TcMEP reproducibility and the surgical team's interpretation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
TcMEP reproducibility and surgical team's interpretation
- TcMEP successfully recorded and interpreted in all patients at both BIS levels
- Alterations in TcMEP parameters did not affect the surgical team's interpretation; not clinically significant
Observational data: associations, not effects.
Secondary outcomes
Mean
| Outcome | BIS40 | P value |
|---|---|---|
| Relativized TcMEP amplitude at BIS40 (% of BIS60) | 78.7% (SD 15.0) | P < 0.001 |
| Relativized TcMEP latency at BIS40 (% of BIS60) | 102.7% (SD 2.9) | P < 0.001 |
Original publication
The Influence of Depth of Anesthesia on Motor Evoked Potentials Monitoring During Spinal Surgery in Youth: A Single-Center Prospective Study (SCOL Study). Anesth Analg. Published 12 June 2026. doi:10.
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