Respiratory failure & ventilation
Relationship Between Intra-Abdominal pressure and microaspiration of gastric contents in critically ill mechanically ventilated patients
Main finding · Pepsin in bronchial secretions vs IAPResult — go to the resultOdds ratio 1.463 95% CI 1.061–1.620Authors' conclusion
In conclusion, our results show that pepsin in bronchial secretions may be elevated when IAP is increased, indicating microaspiration and potentially VAP.
Study context
- Population
- Mechanically ventilated patients in an academic ICU in Greece
- Participants
- 68 vs 10
- Exposure
- Mechanically ventilated patients vs control subjects
- Patientsn = 68
- Controlsn = 10reference
- Outcome
- Pepsin levels in bronchial secretions (microaspiration) in relation to IAP
- Follow-up
- Within 14 days
Methodological detailssingle-centre, controlled
- Single-centre
- Controlled
Main finding
Pepsin in bronchial secretions vs IAP
Odds ratio
1.463
95% CI 1.061–1.620
P = 0.014
Mechanically ventilated patients vs control subjects
OR 1.463 (95% CI 1.061–1.620); P = 0.014
As reported in the abstract
- Correlation of pepsin with intra-abdominal pressure (IAP) (r)
- 0.61
Observational data: associations, not effects.
Further findings
- Pepsin higher in patients with ventilator-associated pneumonia (VAP)
- IAP independently associated with VAP
- Indication towards increased VAP with increased pepsin
Original publication
Relationship Between Intra-Abdominal pressure and microaspiration of gastric contents in critically ill mechanically ventilated patients. J Crit Care. Published 8 December 2022. doi:10.
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