Respiratory failure & ventilation
A specialist-led interprofessional weaning program to prevent weaning failure in high-risk patients: the PRiVENT study
Primary result · Successful weaning at ICU dischargeResult — go to the resultOdds ratio 1.46 95% CI 0.99–2.17Authors' conclusion
The PRiVENT intervention was feasible and successful weaning was numerically more frequent in the intervention group, although the prespecified adjusted primary analysis did not reach statistical significance.
Study context
- Population
- Mechanically ventilated patients at high risk of weaning failure, screened 96 h to 11 days after intubationprimary analysis
- Participants
- 349 vs 1,768
- Comparison
- Specialist-led interprofessional weaning program vs control
- Interventionn = 349
- Controlsn = 1,768reference
- Primary endpoint
- Successful weaning
- Follow-up
- ICU discharge
Methodological detailsmulticentre, claims-data parallel control, prespecified propensity-score matched analysis
- Multicentre
- Claims-data parallel control
- Prespecified propensity-score matched analysis
Primary result
Successful weaning at ICU discharge
Odds ratio
1.46
95% CI 0.99–2.17
P = 0.057
By group
Intervention vs Controls
OR 1.46 (95% CI 0.99–2.17); P = 0.057
As reported in the abstract
Further findings
| Outcome | Intervention | Controls | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Successful weaning, propensity-score matched analysisPrespecified; matched controls | — not stated in the abstract | 46.4% | 2.90 (1.61–5.24) | P < 0.001 | |
| Successful weaning, ICU survivorsExploratory analysis | 2.10 (1.09–4.04) | P = 0.026 | |||
| 0.20.5125Odds ratio (log scale) |
— not stated in the abstract
| Outcome | Intervention | Controls |
|---|---|---|
| Transfer to specialized weaning center | 16.3% | — not stated in the abstract |
— not stated in the abstract
Transfer to specialized weaning center
- Transferred patients had longer ventilation durations, contributing to longer overall invasive mechanical ventilation (IMV) duration in the intervention group
Original publication
A specialist-led interprofessional weaning program to prevent weaning failure in high-risk patients: the PRiVENT study. Crit Care. Published 30 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →