Relationship between muscle mass ratio and rocuronium dose required for maintaining deep neuromuscular blockade: A prospective observational study
Authors' conclusion
No correlation was detected between muscle mass ratio and the rocuronium dose required to achieve deep NMB.
Study context
- Population
- Adult female patients undergoing laparoscopic operation with deep neuromuscular blockade (NMB) (post-tetanic count 1–2) maintained by continuous rocuronium infusion
- Participants
- 90 patients
- Outcome
- Correlation between rocuronium dose required for deep NMB and muscle mass ratio (bioelectric impedance analysis)
Main finding
As reported in the abstract
Correlation of muscle mass ratio with rocuronium dose for deep NMB
No relationship between muscle mass ratio and rocuronium dose (correlation r)
r = 0.059
95% CI = 0.153–0.267p = 0.586
Observational data: associations, not effects.
Secondary outcomes
Fat mass ratio and actual body weight (ABW) vs rocuronium dose
- No correlation with rocuronium dose
Rocuronium onset time
- Positive correlation with muscle mass ratio
- r = 0.327
- Negative correlation with fat mass ratio
- r = −0.302
Profound blockade duration
- No correlation with any assessed variable
Original publication
Relationship between muscle mass ratio and rocuronium dose required for maintaining deep neuromuscular blockade: A prospective observational study. Anaesth Crit Care Pain Med. Published 7 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →