Respiratory failure & ventilation
Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study
Primary resultResult — go to the resultAdjusted cause-specific hazard ratio 0.44 95% CI 0.21–0.90Authors' conclusion
In this large multicenter cohort of mechanically ventilated COVID-19 patients, isolation in negative-pressure ICU rooms was associated with a lower incidence of probable IPA
Study context
- Population
- Mechanically ventilated COVID-19 patients admitted to ICUs in France, Belgium and Switzerland during the first wave of the pandemic
- Participants
- 1,233 participants
- Comparison
- Negative-pressure vs neutral-pressure ICU rooms
- Primary endpoint
- Cumulative incidence of probable invasive pulmonary aspergillosis (IPA), 2024 FUNDICU consensus criteria
Methodological detailsancillary analysis, multicentre
- Ancillary analysis
- Multicentre
Primary result
As reported in the abstract
Adjusted cause-specific hazard ratio
0.44
95% CI 0.21–0.90
P = 0.024
By group
Negative-pressure rooms vs Neutral-pressure rooms
adjusted cause-specific HR 0.44 (95% CI 0.21–0.90); P = 0.024
Secondary outcomes
| Outcome | Negative-pressure rooms | Neutral-pressure rooms | Adjusted cause-specific HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Putative IPA (AspICU algorithm) | 1.3% | 2.1% | 0.65 (0.23–1.77) | P = 0.4 | |
| Putative IPA or Aspergillus colonization (AspICU algorithm) | 3.3% | 5.8% | 0.66 (0.30–1.42) | P = 0.29 | |
| 0.20.5125Adjusted cause-specific hazard ratio (log scale) |
Probable invasive pulmonary aspergillosis (IPA) vs no probable IPA: Invasive mechanical ventilation (IMV) duration and ICU LOS
| Estimate | P value | ||
|---|---|---|---|
| Probable IPA | adjusted HR (IMV duration) 0.45 (95% CI 0.27–0.76) | P = 0.002 | |
| Probable IPA | adjusted HR (ICU LOS) 0.59 (95% CI 0.38–0.91) | P = 0.017 | |
| 0.20.5125Ratio (log scale) |
- Probable IPA associated with longer IMV duration and ICU LOS
Original publication
Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study. Crit Care. Published 25 May 2026. doi:10.
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