Respiratory failure & ventilation
Impact of intensive prone position therapy on outcomes in intubated patients with acute respiratory distress syndrome (ARDS) related to COVID-19
An erratum to this article was published (Ann Intensive Care, 11 Sep 2024 ↗)
Authors' conclusion
This secondary analysis of a large multicenter European cohort of intubated patients with ARDS due to COVID-19 found that intensive PP during the first 48 h did not provide a survival benefit compared to standard PP.
Study context
- Population
- Intubated adults with COVID-19-related ARDS placed in prone positioning (PP) in the first 48 h of intensive care unit (ICU) admission, 149 ICUs in France, Belgium and Switzerlandof 2137 intubated
- Participants
- 753 adults
- Comparison
- Intensive PP vs standard PP in the first 48 h of ICU admission
- Intensive PPn = 79
- Standard PPn = 674reference
- Primary endpoint
- Mortality
- Follow-up
- Day 60
Methodological detailsinternational, inverse probability censoring weighting, target trial emulation
- International
- Inverse probability censoring weighting
- Target trial emulation
Primary result
As reported in the abstract
Intensive PP vs Standard PPHazard ratio (CI)P value
IPCW, complete case analysis
0.95(0.52–1.74)
P = 0.87IPCW, multiple imputation analysis
1.1(0.77–1.57)
P = 0.61Further findings
PP duration in the first 48 h
28-day and 90-day mortality; ventilator-free days until day 28
- Similar in both groups
Original publication
Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19. Ann Intensive Care. Published 27 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →