Respiratory failure & ventilation
Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe Acute Respiratory Distress Syndrome (ARDS): The PRONECMO Randomized Clinical Trial
An erratum to this article was published (JAMA, 6 Feb 2024 ↗)
Authors' conclusion
Among patients with severe ARDS supported by VV-ECMO, prone positioning compared with supine positioning did not significantly reduce time to successful weaning of ECMO.
Study context
- Population
- Patients with severe ARDS undergoing VV-ECMO for less than 48 hours, 14 intensive care units (ICUs) in France, 202194% COVID-19-related ARDS
- Participants
- 170 patients
- Comparison
- Prone vs supine positioning during VV-ECMO
- Prone ECMOn = 86
- Supine ECMOn = 84reference
- Primary endpoint
- Time to successful ECMO weaning
- Follow-up
- 60 days following randomization
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Successful ECMO weaning within 60 days · 60 days
Each group vs supine ECMORisk difference for successful ECMO weaning (95% CI)
Prone ECMO
0.1%(−14.9% to 15.2%)
Each group vs supine ECMOSubdistribution hazard ratio for successful ECMO weaning (95% CI)P value
Prone ECMO
1.11(0.71–1.75)
P = 0.64Secondary outcomes
- 90-day mortality · 90 days — Prone ECMO
- 51%
ICU LOS · 90 days
- No significant difference between prone and supine ECMO
Safety
Serious adverse events during prone position procedure
- No serious adverse events reported
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial. JAMA. Published 26 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →