Relationship between perioperative semaglutide use and residual gastric content: A retrospective analysis of patients undergoing elective upper endoscopy

Silveira, SQ; da Silva, LM; de Campos Vieira Abib, A; de Moura, DTH; de Moura, EGH; Santos, LB; Ho, AM; Nersessian, RSF; Lima, FLM; Silva, MV; Mizubuti, GB

doi:10.1016/j.jclinane.2023.111091

Perioperative medicine & outcomes

Relationship between perioperative semaglutide use and residual gastric content: A retrospective analysis of patients undergoing elective upper endoscopy

J Clin AnesthPublished 2 Mar 2023Retrospective cohort study

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Authors' conclusion

Semaglutide was associated with increased RGC in patients undergoing elective esophagogastroduodenoscopy. Digestive symptoms prior to esophagogastroduodenoscopy were also predictive of increased RGC.

Study context

Population: Patients undergoing elective esophagogastroduodenoscopy under deep sedation/GA, tertiary hospital, July/2021-March/2022of 886 EGDs
Participants: 404 patients

Exposure: Semaglutide within 30 days before EGD vs no semaglutide
SGn = 33
NSGn = 371reference
Outcome: Presence of increased RGC

Methodological detailssingle-centre, retrospective electronic chart review, propensity weighted analysis

Single-centre
Retrospective electronic chart review
Propensity weighted analysis

Main finding

As reported in the abstract

SG24.2%8 of 33

NSG5.1%19 of 371

P < 0.001

Semaglutide use associated with increased residual gastric content (RGC) in the propensity weighted analysis: 5.15 (95%CI 1.92-12.92)

Observational data: associations, not effects.

Further findings

Time of preoperative semaglutide interruption, SG with vs without increased RGC

P = 0.54

With increased RGCmean 10.5 daysSD 5.5

Without increased RGCmean 10.2 daysSD 5.6

Preoperative digestive symptoms and increased RGC

Digestive symptoms (nausea/vomiting, dyspepsia, abdominal distension) associated with increased RGC: 3.56 (95%CI 2.2-5.78)

Propensity weighted analysis

EGD combined with colonoscopy and increased RGC

Protective effect against increased RGC: 0.25 (95%CI 0.16-0.39)

Amount/volume of RGC

No relationship between semaglutide use and amount/volume of RGC: P = 0.99

Safety

Pulmonary aspiration · only one case reported — SG: 1 events

Original publication

Relationship between perioperative semaglutide use and residual gastric content: A retrospective analysis of patients undergoing elective upper endoscopy. J Clin Anesth. Published 2 March 2023. doi:10.1016/j.jclinane.2023.111091

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