Perioperative medicine & outcomes
Effect of various perioperative semaglutide interruption intervals on residual gastric content assessed by esophagogastroduodenoscopy: A retrospective single center observational study
Authors' conclusion
Perioperative semaglutide use is associated with increased RGC in patients undergoing elective esophagogastroduodenoscopy. Preoperative discontinuation of > 21 days and > 14 days in patients with and without ongoing digestive symptoms, respectively, resulted in RGC similar to non-semaglutide users.
Study context
- Population
- Patients undergoing esophagogastroduodenoscopy under deep sedation/GA at a tertiary hospital, July/2021-July/2023
- Participants
- 1,094 patients
- Exposure
- SG vs NSG
- SGn = 123
- NSGn = 971reference
- Outcome
- Increased residual gastric content (any solid content, or > 0.8 mL/Kg of fluid content)
Methodological detailssingle-centre, retrospective chart review, inverse probability treatment weighting
- Single-centre
- Retrospective chart review
- Inverse probability treatment weighting
Main finding
As reported in the abstract
Increased RGC
P < 0.001
- Increased residual gastric content (RGC) overall
- 56 (5.12%)
Observational data: associations, not effects.
Further findings
Factors associated with increased RGC (weighted analysis)
| OR (95% CI) | ||
|---|---|---|
| Ongoing digestive symptoms pre-esophagogastroduodenoscopy | 15.1 (9.85–23.45) | |
| Semaglutide interruption < 8 days | 10.0 (6.67–15.65) | |
| Semaglutide interruption 8-14 days | 4.59 (2.91–7.37) | |
| 0.050.21520Odds ratio (log scale) |
Interruption > 14 days without digestive symptoms (IPTW-adjusted)
| OR (95% CI) | ||
|---|---|---|
| Interruption > 14 days, no digestive symptomsNo association with increased RGC · inverse probability treatment weighting | 0.77 (0.22–2.01) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Effect of various perioperative semaglutide interruption intervals on residual gastric content assessed by esophagogastroduodenoscopy: A retrospective single center observational study. J Clin Anesth. Published 30 October 2024. doi:10.
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