Neuroanesthesia & neurocritical care
Relationship between the amplitudes of cerebral blood flow velocity and intracranial pressure using linear and non-linear approach
Authors' conclusion
Our results indicate that while the grouped-averaged AmpCBFV and AMP were not significantly correlated, either at baseline or during hypocapnia, significant changes were observed when using RAMP and JSA indices.
Study context
- Population
- Traumatic brain injury (TBI) patients hospitalised at Addenbrooke's Hospital with intracranial pressure (ICP) and CBFV monitored during mild hypocapnia
- Participants
- 29 patients
- Exposure
- Baseline vs mild hypocapnia
- Outcome
- Correlation between AmpCBFV and AMP (linear RAMP index; nonlinear JSAsym)
Main finding
As reported in the abstract
- Mean AmpCBFV and AMP not significantly correlated at baseline
- r = - 0.10
- Mean AmpCBFV and AMP not significantly correlated during hypocapnia
- r = - 0.19
- RAMP index at baseline (higher vs hypocapnia, p = 0.035)
- 0.64 ± 0.04
- RAMP index during hypocapnia
- 0.57 ± 0.04
- JSAsym during hypocapnia (decreased vs baseline, p = 0.004)
- 0.35 ± 0.30
- JSAsym at baseline
- 0.44 ± 0.030
Observational data: associations, not effects.
Further findings
| Outcome | Baseline | Hypocapnia | P value |
|---|---|---|---|
| RAMP index (moving-window correlation between AmpCBFV and AMP)Significantly higher at baseline | 0.64 ± 0.04 | 0.57 ± 0.04 | P = 0.035 |
| Relative frequency of symmetrical word types (JSAsym)Decreased during hypocapnia | 0.44 ± 0.030 | 0.35 ± 0.30 | P = 0.004 |
Original publication
Relationship between the amplitudes of cerebral blood flow velocity and intracranial pressure using linear and non-linear approach. J Clin Monit Comput. Published 10 December 2024. doi:10.
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