Relevance of Protein Intake for Weaning in the Mechanically Ventilated Critically Ill: Analysis of a Large International Database
Authors' conclusion
The duration of MV does not appear to depend on protein intake, whereas mortality in patients requiring MV may be improved by a standard protein intake. Adverse effects of a high protein intake cannot be excluded.
Study context
- Population
- Critically ill patients in ICU ≥96 hours requiring mechanical ventilation (MV) by day 4 after ICU admission, 785 international ICUs
- Participants
- 12,930 patients · 785 ICUs
- Comparison
- Protein intake categories and hypothetical protein diets
- Primary endpoint
- Time to successful weaning and death in patients requiring MV (competing risks)
Methodological detailsmulticentre, competing risks analysis
- Multicentre
- Competing risks analysis
Primary result
As reported in the abstract
Death in patients requiring MV and successful weaning (competing risks), by protein intake
Estimate (95% CI)
Standard vs Lowvs exclusively low protein intake
aHR for death in MV (minimum) 0.60(0.45–0.80)
Early high vs Standardtrend to higher risk of death
aHR for death in MV (maximum) 1.35(0.99–1.85)
Original publication
Relevance of Protein Intake for Weaning in the Mechanically Ventilated Critically Ill: Analysis of a Large International Database. Crit Care Med. Published 29 December 2023. doi:10.
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