Cardiac arrest & resuscitation
Renal Dysfunction Modifies the Prognostic Value of Lactate Clearance in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Interaction Analysis
Main finding · Interaction lactate clearance × elevated creatinine for survivalResult — go to the resultInteraction OR 0.63 95% CI 0.45–0.87Authors' conclusion
Among patients undergoing ECPR who survive to 24 hours, elevated creatinine defines an interpretation boundary for percentage-based lactate clearance.
Study context
- Population
- Patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR), single tertiary academic medical center99 analysed
- Participants
- 158 patients
- Exposure
- Elevated creatinine vs Normal creatinine
- Outcome
- Survival to discharge (prognostic value of 24-hour lactate clearance; interaction with elevated 24-hour creatinine)
Methodological details24-hour landmark approach, single-centre
- 24-hour landmark approach
- Single-centre
Main finding
As reported in the abstract
Interaction lactate clearance × elevated creatinine for survival
Interaction OR
0.63
95% CI 0.45–0.87
P = 0.005
By group
Normal creatinine
- OR
- 1.30
- AUROC
- 0.654
Elevated creatinine
- OR
- 0.98
- AUROC
- 0.516
OR
Normal creatinine1.30
Elevated creatinine0.98
AUROC
Normal creatinine0.654
Elevated creatinine0.516
Elevated creatinine vs Normal creatinine
interaction OR 0.63 (95% CI 0.45–0.87); P = 0.005
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Renal Dysfunction Modifies the Prognostic Value of Lactate Clearance in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Interaction Analysis. J Cardiothorac Vasc Anesth. Published 10 June 2026. doi:10.
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