Cardiac arrest & resuscitation
Lactate and lactate clearance as predictors of one-year survival in extracorporeal cardiopulmonary resuscitation – An international, multicentre cohort study
Authors' conclusion
Pre-ECPR lactate levels and 24 hour-lactate clearance after ECPR initiation in patients with refractory cardiac arrest were level-dependently associated with one-year survival.
Study context
- Population
- Adults with refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR) at 3 German and 4 Danish tertiary cardiac care centres, 2011–202165 (22%) survived
- Participants
- 297 adults
- Exposure
- Pre-ECPR lactate and 24-hour lactate clearance tertiles
- Outcome
- One-year survival
- Follow-up
- One year
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
As reported in the abstract
Odds ratio (95% CI)
Lowest pre-ECPR lactate vs Highest pre-ECPR lactate
5.40(2.30–13.60)
Lowest 24-hour lactate clearance vs Highest 24-hour lactate clearance
0.25(0.09–0.68)
Observational data: associations, not effects.
Further findings
Survival, Kaplan-Meier analyses
- Results confirmed in Kaplan-Meier analyses (each p log rank < 0.001) and subgroup analyses
Original publication
Lactate and lactate clearance as predictors of one-year survival in extracorporeal cardiopulmonary resuscitation – An international, multicentre cohort study. Resuscitation. Published 23 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →