Renal outcomes following intravenous contrast administration in patients with acute kidney injury: a multi-site retrospective propensity-adjusted analysis
Authors' conclusion
Among patients with pre-existing AKI, contrast administration was not associated with either persistent AKI at hospital discharge or initiation of dialysis within 180 days.
Study context
- Population
- Consecutive hospitalized adults (≥ 18 years) meeting Kidney Disease Improving Global Outcomes (KDIGO) creatinine-based criteria for acute kidney injury (AKI) on arrival to one of three EDs, 7/1/2017–6/30/2021
- Participants
- 14,449 patient encounters
- Exposure
- Intravenous contrast media vs no contrast media
- Outcome
- Persistent AKI at hospital discharge
- Follow-up
- Hospital discharge
Methodological detailspropensity-weighted, entropy-balanced, multi-site
- Propensity-weighted
- Entropy-balanced
- Multi-site
Main finding
As reported in the abstract
CM vs No CMOdds ratio (95% CI)
Unadjusted multivariable logistic regression
1(0.89–1.11)
Propensity weighting
0.93(0.83–1.05)
Entropy balancing
0.94(0.83–1.05)
Observational data: associations, not effects.
Further findings
Persistent AKI, intensive care unit (ICU) subgroup (subgroup)
- Similar results in those admitted to the ICU
Initiation of dialysis · within 180 days
- Dialysis initiated in whole cohort
- 5.4%
- No association between contrast media (CM) and increased risk of dialysis
Cohort characteristics
- Admitted to ICU
- 12.8%
- CM administered
- 18.4%
- AKI resolved before discharge
- 69.1%
Original publication
Renal outcomes following intravenous contrast administration in patients with acute kidney injury: a multi-site retrospective propensity-adjusted analysis. Intensive Care Med. Published 30 January 2023. doi:10.
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