Perioperative medicine & outcomes
Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review
Authors' conclusion
Our scoping review showed that elevated serum renin levels may be associated with clinically relevant outcomes among various perioperative and intensive care populations.
Study context
- Population
- Critically ill and perioperative patients (shock, nonspecific critical illness, cardiac surgery, noncardiac surgery, coronavirus disease)
- Participants
- 1,573 participants · 16 studies
- Outcome
- Mortality
- Follow-up
- Longest
Methodological detailsSearched PubMed, Embase and the Cochrane Library from inception to March 31, 2023; 2081 studies identified
- Searched PubMed, Embase and the Cochrane Library from inception to March 31, 2023; 2081 studies identified
Main finding
As reported in the abstract
Association of serum renin with outcomes
Studies showing a significant association between serum renin and poor outcomes
14
Studies showing an association with mortality
10
Secondary outcomes
Angiotensin II administration and mortality in patients with markedly elevated renin (post hoc analysis)
- Angiotensin II reduced mortality in 1 post hoc analysis
Prognostic performance for mortality vs lactate
- Studies showing renin superior to lactate
- 2
Original publication
Renin as a Prognostic Marker in Intensive Care and Perioperative Settings: A Scoping Review. Anesth Analg. Published 24 October 2023. doi:10.
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