ICU sedation, delirium & recovery
Reproducibility and precision of renal perfusion quantification with contrast enhanced ultrasound in critically ill patients: a prospective observational study
Authors' conclusion
Under controlled conditions, CEUS derived parameters are reproducible and have a fair precision in critically ill patients in stable hemodynamic condition. mTT might be more reliable under varying infusion conditions.
Study context
- Population
- Critically ill patients in stable cardio-pulmonary condition
- Participants
- 20 patients
- Exposure
- Group 1 vs Group 2
- Group 1n = 10
- Group 2n = 10
- Outcome
- Reproducibility and precision of CEUS-derived renal perfusion parameters (relative blood volume, mean transit time, perfusion index)
Main finding
As reported in the abstract
Reproducibility of CEUS parameters across three timepoints (Group 1)
- Relative blood volume (RBV) across three timepoints
- 3 289 vs. 3 680 vs. 3 590
- Mean transit time (mTT) across three timepoints
- 4.1 vs. 4.2 vs. 4.2
- Perfusion index (PI) across three timepoints
- 684 vs. 762 vs. 735
- All differences across timepoints
- p values > 0.05
- Intra-measure coefficient of variability, RBV
- 23.2%
- Intra-measure coefficient of variability, mTT
- 13.9%
- Intra-measure coefficient of variability, PI
- 33.8%
Observational data: associations, not effects.
Further findings
Effect of doubling ultrasound contrast agent (UCA) rate (Group 2)
- RBV, doubled vs standard UCA rate
- 3 207 vs. 1 624, p = 0.01
- PI, doubled vs standard UCA rate
- 977 vs. 617, p = 0.01
- mTT, doubled vs standard UCA rate
- 4.6 vs. 3.8, p = 0.08
Patient-related factors associated with signal instability
- No patients-related parameter significantly associated with contrast-enhanced ultrasound (CEUS) parameters variability
Original publication
Reproducibility and precision of renal perfusion quantification with contrast enhanced ultrasound in critically ill patients: a prospective observational study. Crit Care. Published 29 October 2025. doi:10.
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