Respiratory Depression Following Intraoperative Methadone: A Retrospective Cohort Study
Main finding · Naloxone administrationResult — go to the resultAdjusted odds ratio 1.21 95% CI 0.40–2.02Authors' conclusion
No difference was observed in the odds of naloxone administration to treat severe RD between patients administered intraoperative methadone or intraoperative morphine. Intraoperative methadone was associated with longer stays at the PACU; however, this result should be interpreted with care.
Study context
- Population
- Patients aged ≥18 years undergoing surgery, Aarhus University Hospital, Denmark, March 2019–March 2023included in the analysis
- Participants
- 14,522 patients
- Exposure
- Intraoperative methadone vs intraoperative morphine
- Methadonen = 2,437
- Outcome
- Postoperative naloxone administration (measure of severe respiratory depression (RD))
- Follow-up
- First 24 hours
Methodological detailspropensity-score weighted, single-centre
- Propensity-score weighted
- Single-centre
Main finding
Naloxone administration · first 24 hours after surgery
Adjusted odds ratio
1.21
95% CI 0.40–2.02
Events by group
Methadone vs Morphine
aOR 1.21 (95% CI 0.40–2.02)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Mean, minutes
| Outcome | Methadone | Morphine | Adjusted ratio of the geometric means (95% CI) | |
|---|---|---|---|---|
| PACU LOS26% longer | 334 (SD 382) | 195 (SD 228) | 1.26 (1.22–1.31) | |
| 0.512Adjusted ratio of the geometric means (log scale) |
Original publication
Respiratory Depression Following Intraoperative Methadone: A Retrospective Cohort Study. Anesth Analg. Published 14 February 2025. doi:10.
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