Respiratory failure & ventilation
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
Authors' conclusion
Among patients with ARDS, systemic inflammatory and vascular permeability markers were independently associated with higher respiratory drive.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients in the EPVent-2 trial with requisite data and plasma biomarkers, excluding NMB recipients
- Participants
- 124 patients
- Comparison
- Lower drive vs Moderate drive vs Higher drive
- Primary endpoint
- Association of systemic inflammation and vascular permeability markers (angiopoietin-2, interleukin-6, interleukin-8) with respiratory drive (PES0.1) and clinical outcomes
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Respiratory drive (PES0.1)
Detectable respiratory drive
54.8%
PES0.1 range
0-5.1 cm H2O
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Risk of death · 60 daysLower drive vs Moderate drive | 1.58 (0.82–3.05) | |
| Risk of death · 60 daysHigher drive vs Moderate drive | 2.63 (1.21–5.70) | |
| 0.20.5125Hazard ratio (log scale) |
- Risk of death: overall p = 0.049
Risk of death · 60 days
- Risk of death less with moderate drive
Original publication
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome. Crit Care. Published 23 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →