Respiratory failure & ventilation
Respiratory Failure Requiring Mechanical Ventilation Among Patients Receiving Chlordiazepoxide for Alcohol Withdrawal Symptoms
Authors' conclusion
Typical presentation of ICU admission was respiratory insufficiency and somnolence after symptom-triggered treatment with chlordiazepoxide for alcohol withdrawal symptoms. Mechanical ventilation was used in more than two-thirds of the admitted patients, and the risk of readmission and fatal outcome was high.
Study context
- Population
- Intensive Care Unit (ICU) admissions to a Danish general ICU after ≥200 mg chlordiazepoxide (symptom-triggered) for alcohol withdrawal symptoms within 10 days before ICU admission
- Participants
- 113 participants · 133 admissions
- Exposure
- "Too sedated" vs "Too agitated"
- Outcome
- Need for mechanical ventilation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Invasive or non-invasive mechanical ventilation
- All ICU admissions
- 71%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Too sedated | Too agitated |
|---|---|---|
| Mortality · 90 days | 21% | 0 events |
Reasons for ICU admission
- Respiratory insufficiency
- 39%
- Somnolence
- 39%
Readmission · 90 days
- Hospital readmission
- 36%
- ICU readmission
- 14%
Original publication
Respiratory Failure Requiring Mechanical Ventilation Among Patients Receiving Chlordiazepoxide for Alcohol Withdrawal Symptoms. Acta Anaesthesiol Scand. Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →