Perioperative medicine & outcomes
Response to a prehabilitation program for patients with oesophageal cancer: an observational study
Authors' conclusion
On average, patients with oesophageal cancer improved in physical fitness and nutritional status during prehabilitation, recovering from the impact of neoadjuvant treatment. Response to prehabilitation was independent of baseline fitness. A greater decline in fitness during neoadjuvant treatment, lower fitness before prehabilitation and higher fatigue were associated with a positive response.
Study context
- Population
- Patients with oesophageal cancer following a 6–10 week personalized prehabilitation program (supervised exercise and nutritional counseling) after neoadjuvant treatment
- Participants
- 240 patients
- Outcome
- Response to prehabilitation (change in exercise capacity and physical fitness)
Methodological detailsmulticenter, observational
- Multicenter
- Observational
Main finding
As reported in the abstract
Increase in exercise capacity during prehabilitation (95% CI 25.2-40.2)
+ 32.7 Watts
Patients following a decline-improvement pattern
49.6%
Responders (> 0 Watt improvement during exercise training)
65%
Observational data: associations, not effects.
Further findings
Factors associated with positive response to prehabilitation
- Greater decline in fitness during neoadjuvant treatment
- P < 0.001
- Lower fitness after neoadjuvant treatment
- P = 0.001
- Higher fatigue
- P = 0.01
Original publication
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