ICU sedation, delirium & recovery
Restricted Polypharmacy Compared to Usual Care in Mechanically Ventilated Patients: A Retrospective Cohort Study
Authors' conclusion
Compared with UC, RP was associated with more coma- and ventilator-free days.
Study context
- Population
- Mechanically ventilated adults in intensive care units (ICUs) of a tertiary-level medical center, initiated on propofol infusion, with >50% probability of continued ventilation for the next 24 hours3,765 followed RP until extubation
- Participants
- 7,974 participants
- Exposure
- Restricted polypharmacy vs usual care
- Outcome
- Coma-free days and ventilator-free days; in-hospital mortality
- Follow-up
- Within 30 days of intubation
Methodological detailstarget trial framework, inverse probability weighting, single-centre
- Target trial framework
- Inverse probability weighting
- Single-centre
Main finding
As reported in the abstract
Coma-free and ventilator-free days
Usual care (UC)
23.5
mean · 95% CI 23.3–23.7 · coma-free days
Each group vs UCEstimate (95% CI)
RP
increase in mean coma-free days 1.0 days(0.7–1.3)
RP
increase in mean ventilator-free days 1.0 days(0.7–1.3)
Observational data: associations, not effects.
Further findings
| Outcome | UC | Confounding-adjusted association (95% CI) |
|---|---|---|
| In-hospital mortalityUninformative | 22.0% (95% CI 21.2–22.8) | −0.5% (−3.0 to 1.9) |
Original publication
Restricted Polypharmacy Compared to Usual Care in Mechanically Ventilated Patients: A Retrospective Cohort Study. Anesth Analg. Published 4 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →