Restrictive Versus Standard Intravenous Fluid Therapy and Endothelial Glycocalyx Shedding in Intensive Care Unit (ICU) Patients With Septic Shock—A Preplanned Sub‐Study of the Randomized CLASSIC Trial
Primary result · Change in plasma hyaluronanResult — go to the resultDifference 11 ng/mL 95% CI 35–41Authors' conclusion
In this underpowered sub-study we found no statistically significant difference in endothelial glycocalyx shedding between adult ICU patients with septic shock randomized to restrictive versus standard IV fluid therapy.
Study context
- Population
- Adult ICU patients with septic shock at one Danish and one Swedish ICU, February 2020–October 2021planned 200
- Participants
- 54 patients
- Comparison
- Restrictive vs standard intravenous (IV) fluid therapy
- Primary endpoint
- Change in plasma hyaluronan levels
- Follow-up
- From T0 (within first hour after randomization) to T1 (following morning)
Methodological detailspreplanned sub-study, two-centre, Plasma glycocalyx shedding markers measured at T0, T1, T2 (the morning after) and T3 (ICU discharge or up to 90 days)
- Preplanned sub-study
- Two-centre
- Plasma glycocalyx shedding markers measured at T0, T1, T2 (the morning after) and T3 (ICU discharge or up to 90 days)
Primary result
Change in plasma hyaluronan · T0 to T1
Difference
11 ng/mL
95% CI 35–41
As reported in the abstract
- Group × time interaction non-significant
- 0.872
Original publication
Restrictive Versus Standard Intravenous Fluid Therapy and Endothelial Glycocalyx Shedding in ICU Patients With Septic Shock—A Preplanned Sub‐Study of the Randomized CLASSIC Trial. Acta Anaesthesiol Scand. Published December 2025. doi:10.
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