Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial
Primary resultResult — go to the resultHodges-Lehmann median difference 3560 ml 95% CI 1614–5302Authors' conclusion
Protocolized reduction of non-resuscitation fluids in patients with septic shock resulted in a large decrease in fluid administration compared with usual care.
Study context
- Population
- Adults with septic shock in six Swedish intensive care unit (ICUs), randomised within 12 h of ICU admission
- Participants
- 98 adults · 6 ICUs
- Comparison
- Protocolized reduction of non-resuscitation fluids vs usual care
- Restrictive fluidn = 44
- Controln = 48reference
- Primary endpoint
- Total volume of fluid administered
- Follow-up
- Within three days of inclusion
Methodological detailsmulticentre, feasibility
- Multicentre
- Feasibility
Primary result
As reported in the abstract
Hodges-Lehmann median difference
3560 ml
95% CI 1614–5302
P < 0.001
By group
Control vs Restrictive fluid
Hodges-Lehmann median difference 3560 ml (95% CI 1614–5302); P < 0.001
Further findings
Feasibility: data completeness
- All-cause mortality within 90 days recorded
- 98/98 (100%)
- Days alive and free of mechanical ventilation within 90 days recorded
- 95/98 (98%)
- AKI or ischemic events in ICU within 90 days recorded
- 95/98 (98%)
- Cognition at six months recorded (surviving participants)
- 39/52 (75%)
- Health-related quality of life at six months recorded (surviving participants)
- 41/52 (79%)
Feasibility: recruitment and protocol adherence
- Eligible patients randomised
- Ninety out of 134 patients (67%)
- Participants with at least one protocol violation
- 15/98 (15%)
Original publication
Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial. Crit Care. Published 17 May 2024. doi:10.
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