Protocolized REDUction of Non‐Resuscitation Fluids in SEptic Shock Patients. A Protocol for the REDUSE Randomized Clinical Trial
Study context
- Population
- Adults admitted to intensive care units (ICUs) with septic shock, randomised within 12 h of admission1,850 planned
- Planned comparison
- Protocolized restrictive non-resuscitation fluids vs usual care
- Primary endpoint
- All-cause mortality
- Follow-up
- Up to 90 days
Methodological detailsprotocolized, Sample size: to detect an absolute mortality reduction of 7.5%, alpha 5%, power 90%, Secondary outcomes: ICU complications (any AKI or cerebral, coronary, intestinal or limb ischaemia) up to 90 days, ventilator-free days within 90 days, cognitive function (MOCA-BLIND) and HRQoL (EQ-VAS) in survivors at 6 months; climate impact of the interventions
- Protocolized
- Sample size: to detect an absolute mortality reduction of 7.5%, alpha 5%, power 90%
- Secondary outcomes: ICU complications (any AKI or cerebral, coronary, intestinal or limb ischaemia) up to 90 days, ventilator-free days within 90 days, cognitive function (MOCA-BLIND) and HRQoL (EQ-VAS) in survivors at 6 months; climate impact of the interventions
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Protocolized REDUction of Non‐Resuscitation Fluids in SEptic Shock Patients. A Protocol for the REDUSE Randomized Clinical Trial. Acta Anaesthesiol Scand. Published 16 July 2025. doi:10.
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