Perioperative medicine & outcomes
Restrictive versus conventional ward fluid therapy in non-cardiac surgery patients and the effect on postoperative complications: a meta-analysis
Authors' conclusion
This meta-analysis suggests restrictive fluid therapy on the ward may be associated with an effect on postoperative complication rate.
Study context
- Population
- Adults after non-cardiac surgery, postoperative period on the clinical ward
- Participants
- 883 adults · 3 RCTs · 4 non-randomised studies
- Comparison
- Restrictive vs conventional ward fluid regimen
- Outcome
- Overall complication rate
Methodological detailsRisk of bias moderate to high; methodological quality very low to moderate
- Risk of bias moderate to high; methodological quality very low to moderate
Pooled result
As reported in the abstract
Restrictive vs ConventionalRelative risk (95% CI)P value
RCTs; I2 = 35%
0.46(0.23–0.95)
P < 0.03Non-randomised studies; I2 = 45%
0.74(0.53–1.03)
P 0.07Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| MortalityRestrictive vs Conventional · RCTs; I2 = 0% | 0.51 (0.05–4.90) | P = 0.56 | |
| MortalityRestrictive vs Conventional · non-randomised studies; I2 = 0% | 0.30 (0.06–1.46) | P = 0.14 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | MD (days) (95% CI) | P value |
|---|---|---|
| Postoperative LOSRestrictive vs Conventional · non-randomised studies; I2 = 0% | - 1.81 (- 3.27 to - 0.35) | P = 0.01 |
| Postoperative LOSRestrictive vs Conventional · RCTs | 0.60 (- 0.75 to 1.95) | P = 0.38 |
Original publication
Restrictive versus conventional ward fluid therapy in non-cardiac surgery patients and the effect on postoperative complications: a meta-analysis. Perioper Med (Lond). Published 21 September 2023. doi:10.
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