Hemodynamics, fluids & transfusion
A retrospective Cohort study on the effect of the LOw-molecular weighT heparin (LMWH) nadroparin dose on anti-XA levels in a mixed medical-surgical ICU population: CLOT-Xa
Authors' conclusion
We found a clear dose-response relationship between nadroparin dose and anti-Xa levels.
Study context
- Population
- Critically ill adults in a mixed medical-surgical ICU receiving ≥3 SC injections of nadroparin1,520 anti-Xa measurements
- Participants
- 327 adults
- Exposure
- Nadroparin dose categories vs anti-Xa level
- Outcome
- Dose-response relationship between nadroparin dose and anti-Xa activity
Methodological detailsmixed-effects logistic regression
- Mixed-effects logistic regression
Main finding
As reported in the abstract
Median anti-Xa level by nadroparin dose
0-37 IU/kg/day
<0.1
median · IU/mL
>85 IU/kg/day
0.6
median · IU/mL
P < 0.01
Observational data: associations, not effects.
Further findings
- Anti-Xa in desired range — 38-85 IU/kg
- 73 %
- Anti-Xa in desired range — All measurements in desired range
- 859 (57 %) of 1520
Anti-Xa in desired range
- Best adequacy of anti-Xa levels at 38-85 IU/kg
Safety
- No differences in the odds of bleeding events or venous thromboembolism (VTE) between anti-Xa levels
Original publication
A retrospective Cohort study on the effect of the LOw-molecular weighT heparin (LMWH) nadroparin dose on anti-XA levels in a mixed medical-surgical ICU population: CLOT-Xa. J Crit Care. Published 17 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →