Hemodynamics, fluids & transfusion
The effect of heparins on plasma concentration of heparin-binding protein: a pilot study
Authors' conclusion
Plasma concentrations of HBP increased rapidly and dose-dependently after heparin administration. Subcutaneous administration of LMWH increases plasma HBP, but to a lesser degree.
Study context
- Population
- Patients receiving heparins during or after surgery
- Exposure
- Plasma heparin-binding protein (HBP) before vs after heparin
- Outcome
- Plasma HBP concentration after heparin
Main finding
As reported in the abstract
Plasma HBP (ng ml-1), baseline to post-heparin
- Vascular surgery: HBP from 3.6 (2.4-5.4) to 21.4 (9.0-35.4) ng ml-1 within 2 min, six-fold increase
- P<0.001
- Cardiac surgery: HBP from 5.3 (2.7-6.1) to 48.7 (38.4-70.1) ng ml-1 within 3 min
- P<0.0001
- Low-molecular-weight heparin (LMWH): HBP from baseline 5.7 (3.7-12.1) to peak 14.8 (9.5-18.1) ng ml-1 after 3 h
- P<0.0001
Observational data: associations, not effects.
Further findings
Plasma myeloperoxidase and syndecan-1 (Cardiac surgery)
- Myeloperoxidase rapidly increased after heparin; syndecan-1 did not
Agreement between Axis-Shield ELISA and Joinstar FIC-Q100 for HBP
- Strong correlation (r)
- 0.94
Original publication
The effect of heparins on plasma concentration of heparin-binding protein: a pilot study. BJA Open. Published 27 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →