Cardiothoracic & vascular anesthesia
Anticoagulation Monitoring Strategies During Cardiopulmonary Bypass in Patients With Antiphospholipid Syndrome: A Systematic Review
Authors' conclusion
Anticoagulation monitoring during CPB in patients with APS remains heterogeneous and insufficiently standardized.
Study context
- Population
- Patients with confirmed antiphospholipid syndrome (APS) undergoing cardiac or cardiovascular surgery using cardiopulmonary bypass (CPB) with heparin anticoagulation17 studies
- Participants
- 25 / 25 / 1
- Comparison
- Activated clotting time (ACT) vs Hepcon vs Heparin-ACT titration
- ACTn = 25
- Hepconn = 25
- Heparin-ACT titrationn = 1
- Outcome
- Anticoagulation monitoring strategies
Methodological detailsPRISMA 2020-compliant
- PRISMA 2020-compliant
Pooled result
As reported in the abstract
- Most studies used multimodal monitoring approaches
- Heterogeneous use of monitoring strategies and recurrent concerns regarding reliability of ACT alone
Safety
- Perioperative complications among 62 patients
- 15
- Predominantly from a single cohort study that contributed the majority of quantitative outcome data
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Anticoagulation Monitoring Strategies During Cardiopulmonary Bypass in Patients With Antiphospholipid Syndrome: A Systematic Review. J Cardiothorac Vasc Anesth. Published 17 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →