Cardiothoracic & vascular anesthesia
TEG® 6s Heparin Neutralization Cartridge for Hemostatic Assessment of Patients Undergoing Cardiovascular Surgery
Authors' conclusion
This study provided clinical validation for the TEG 6s heparin neutralization cartridge for point-of-care coagulation testing in patients undergoing cardiovascular surgeries or procedures.
Study context
- Population
- Adults undergoing cardiovascular surgery/invasive cardiac procedures with planned unfractionated heparin, with or without CPB543 samples
- Participants
- 185 adults
- Comparison
- TEG 6s heparin neutralization cartridge assays vs identical assays on the citrated multichannel cartridge; functional fibrinogen with heparinase vs Clauss plasma fibrinogen
- Outcome
- Agreement between assays
Methodological detailsmulticentre, observational, 113 cardiovascular surgery with CPB; 72 procedures without CPB, Samples before heparin, after heparin and after heparin reversal (or end of procedure without protamine)
- Multicentre
- Observational
- 113 cardiovascular surgery with CPB; 72 procedures without CPB
- Samples before heparin, after heparin and after heparin reversal (or end of procedure without protamine)
Performance
As reported in the abstract
Deming regression slopes, heparin neutralization vs citrated multichannel cartridge
equal to/≈1.0
Pearson correlation coefficients, heparin neutralization vs citrated multichannel cartridge
0.79 to 0.96
Spearman correlation, functional fibrinogen with heparinase vs plasma fibrinogen
0.68
Further findings
- Adding heparinase to RapidTEG and functional fibrinogen assays gave more analyzable samples than without heparinase
Original publication
TEG® 6s Heparin Neutralization Cartridge for Hemostatic Assessment of Patients Undergoing Cardiovascular Surgery. Anesthesiology. Published 18 September 2025. doi:10.
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