Cardiothoracic & vascular anesthesia
Changes in the Relationship Between Plasma Fibrinogen Concentration and Functional Clot Strength After Cardiopulmonary Bypass: A Retrospective Observational Study
Authors' conclusion
The association between fibrinogen concentration and functional clot strength changes significantly after CPB, with contrasting trends in TEG and Quantra.
Study context
- Population
- Adults undergoing cardiovascular surgery with cardiopulmonary bypass (CPB), cardiovascular surgery center in Japan
- Participants
- 170 vs 79
- Exposure
- Citrated functional fibrinogen (CFF) vs FCS
- CFFn = 170
- FCSn = 79
- Outcome
- Regression of CFF and FCS against Clauss fibrinogen
- Follow-up
- T1, T2, T3
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
CFF slope T1 → T2 (p < 0.05), returned at T3
6.12 → 8.69 → 6.58
CFF intercept decreased significantly at T2
0.29 → −8.39
FCS slope T1 → T2 → T3
1.66 → 0.61 → 0.72
FCS intercept increased
−3.55 → −0.32
Observational data: associations, not effects.
Further findings
Conventional coagulation tests
- Prolonged prothrombin time/activated partial thromboplastin time, decreased hemoglobin and platelet counts, elevated thrombin antithrombin complex, fibrin/fibrinogen degradation products and D-dimer
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Changes in the Relationship Between Plasma Fibrinogen Concentration and Functional Clot Strength After Cardiopulmonary Bypass: A Retrospective Observational Study. J Cardiothorac Vasc Anesth. Published 3 September 2025. doi:10.
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