Cardiothoracic & vascular anesthesia
Efficacy of Quantra-Qplus System for Rapid Diagnosis and Treatment of Hypofibrinogenemia and Thrombocytopenia After Cardiopulmonary Bypass
Authors' conclusion
Our study provides potential cutoff values of FCS and PCS to guide fibrinogen administration or platelet transfusion in cardiac surgery patients after protamine administration.
Study context
- Population
- Adults undergoing cardiac surgery with CPB, single-centre university hospital
- Participants
- 50 adults
- Exposure
- FCS vs PCS
- Outcome
- Cutoff values predicting transfusion thresholds
- Follow-up
- After protamine administration
Methodological detailssingle-centre, Blood samples at 4 times: preoperative, during CPB, after protamine, end of surgery
- Single-centre
- Blood samples at 4 times: preoperative, during CPB, after protamine, end of surgery
Main finding
As reported in the abstract
| Group | Value | AUC | 95% CI | Target |
|---|---|---|---|---|
| FCS | cutoff 0.95 hPa | 0.94 | 0.86-1.00 | fibrinogen concentration less than 150 mg/dL |
| PCS | cutoff 7.05 hPa | 0.97 | 0.92-1.00 | platelet count less than 50,000/mm3 |
Value
FCScutoff 0.95 hPa
PCScutoff 7.05 hPa
AUC
FCS0.94
PCS0.97
95% CI
FCS0.86-1.00
PCS0.92-1.00
Target
FCSfibrinogen concentration less than 150 mg/dL
PCSplatelet count less than 50,000/mm3
Observational data: associations, not effects.
Further findings
- Cutoff values of FCS and PCS varied during cardiac surgery
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Efficacy of Quantra-Qplus System for Rapid Diagnosis and Treatment of Hypofibrinogenemia and Thrombocytopenia After Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. Published 9 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →