Cardiothoracic & vascular anesthesia
Sonorheometry Quantra QPlus Characteristics in Adult Cardiac Surgical Patients: An Observational Cohort Study
Authors' conclusion
CTH, PCS, and FCS demonstrated high discriminative accuracy for abnormalities in corresponding laboratory assays. CPB and hypofibrinogenemia modified the relationship between PCS and platelet count, with a higher platelet count observed for a given PCS during CPB and when fibrinogen was low.
Study context
- Population
- Adult cardiac surgical patients, single academic medical center, first year of routine sonorheometry (2024–2025)
- Participants
- 511 patients
- Exposure
- Quantra QPlus parameters vs paired reference laboratory assays
- Outcome
- Accuracy of Quantra QPlus in detecting derangements in traditional coagulation tests
Methodological detailssingle-centre, diagnostic accuracy (ROC analysis), multivariable linear regression
- Single-centre
- Diagnostic accuracy (ROC analysis)
- Multivariable linear regression
Main finding
As reported in the abstract
Discrimination of laboratory abnormalities
| Group | Threshold for elevated international normalized ratio (INR) post-CPB | AUC | Threshold for hypofibrinogenemia post-CPB | Threshold for thrombocytopenia post-CPB | AUC post-CPB | Threshold for thrombocytopenia on-CPB | AUC on-CPB |
|---|---|---|---|---|---|---|---|
| Clot time heparinase (CTH) | 153 seconds | 0.78 to 0.84 | |||||
| FCS | 0.88 to 0.97 | 1.5 to 2.3 hPa | |||||
| PCS | 6.9 to 12.2 hPa | 0.90 to 0.97 | 9.1 to 12.1 hPa | 0.92 to 0.98 |
Threshold for elevated international normalized ratio (INR) post-CPB
Clot time heparinase (CTH)153 seconds
FCS— not stated in the abstract
PCS— not stated in the abstract
AUC
Clot time heparinase (CTH)0.78 to 0.84
FCS0.88 to 0.97
PCS— not stated in the abstract
Threshold for hypofibrinogenemia post-CPB
Clot time heparinase (CTH)— not stated in the abstract
FCS1.5 to 2.3 hPa
PCS— not stated in the abstract
Threshold for thrombocytopenia post-CPB
Clot time heparinase (CTH)— not stated in the abstract
FCS— not stated in the abstract
PCS6.9 to 12.2 hPa
AUC post-CPB
Clot time heparinase (CTH)— not stated in the abstract
FCS— not stated in the abstract
PCS0.90 to 0.97
Threshold for thrombocytopenia on-CPB
Clot time heparinase (CTH)— not stated in the abstract
FCS— not stated in the abstract
PCS9.1 to 12.1 hPa
AUC on-CPB
Clot time heparinase (CTH)— not stated in the abstract
FCS— not stated in the abstract
PCS0.92 to 0.98
Observational data: associations, not effects.
Further findings
Modification of PCS–platelet count relationship by cardiopulmonary bypass (CPB) and hypofibrinogenemia
- Higher platelet count for a given PCS during CPB (β)
- 1.51
- Higher platelet count for a given PCS with FCS 1.6-2.3 hPa (β)
- 3.13
- Higher platelet count for a given PCS with FCS ≤1.5 hPa (β)
- 4.04
Original publication
Sonorheometry Quantra QPlus Characteristics in Adult Cardiac Surgical Patients: An Observational Cohort Study. Anesth Analg. Published 20 July 2026. doi:10.
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