Cardiothoracic & vascular anesthesia
Comparison between the Fibrinogen Clauss Assay and the TEG6S Citrated Functional Fibrinogen in Cardiac Surgery
Authors' conclusion
The TEG6s CFF assay demonstrates a strong correlation with Clauss fibrinogen levels before CPB, but this relationship weakens during CPB and remains moderate post-protamine administration.
Study context
- Population
- Adults (≥18 years) scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB), single tertiary academic centre60 paired measurements
- Participants
- 20 adults
- Exposure
- TEG6s citrated functional fibrinogen (CFF) vs Clauss fibrinogen assay
- Outcome
- Correlation between TEG6s CFF and Clauss fibrinogen values across surgical phases (baseline pre-CPB, rewarming during CPB, 5 min post-protamine)
Methodological detailssingle-centre, method comparison
- Single-centre
- Method comparison
Main finding
As reported in the abstract
Correlation of CFF with Clauss fibrinogen
- Strong correlation at baseline (Spearman's ρ = high)
- p < 0.01
- Correlation significantly weakened during rewarming
- p < 0.05
Observational data: associations, not effects.
Further findings
Turnaround time
- Significantly faster for CFF than Clauss across all phases
Prediction of major postoperative bleeding (≥500 mL chest tube output in 24 hours)
- CFF values alone did not reliably predict major postoperative bleeding
- Neither assay showed statistically significant differences between bleeding and nonbleeding groups
Original publication
Comparison between the Fibrinogen Clauss Assay and the TEG6S Citrated Functional Fibrinogen in Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 18 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →