Cardiac arrest & resuscitation
Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a secondary analysis of the SAVE-J II study
Primary result · Bleeding complications during the first day of admissionResult — go to the resultAdjusted odds ratio 1.865 CI 1.252–2.777Authors' conclusion
In a large ECPR registry database in Japan, up to 22.1% of patients experienced bleeding complications requiring blood transfusion, IVR, or surgical intervention for hemostasis. The initial platelet count was a significant risk factor of early bleeding complications.
Study context
- Population
- Adult out-of-hospital cardiac arrest (OHCA) patients receiving extracorporeal cardiopulmonary resuscitation (ECPR), 36 institutions in Japan, 2013–2018
- Participants
- 1,632 patients · 36 institutions
- Comparison
- Platelet count <10 × 104/μL vs >10 × 104/μL
- Primary endpoint
- Risk factors of bleeding complications during the first day of admission
- Follow-up
- First day of admission
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Primary result
As reported in the abstract
Bleeding complications during the first day of admission
Adjusted odds ratio
1.865
CI 1.252–2.777
P = 0.002
Platelet count < 10 × 104/μL vs Platelet count > 10 × 104/μL
aOR 1.865 (CI 1.252–2.777); P = 0.002
Secondary outcomes
Bleeding complications during hospital stay
- Any bleeding complication
- 361 (22.1%)
- Cannulation sites
- 14.3%
- Retroperitoneum
- 2.8%
- Gastrointestinal tract
- 2.2%
- Upper airway
- 1.2%
- Mediastinum
- 1.1%
- Required interventional radiology (IVR) or/and surgical hemostasis
- 21.9%
- Onset within two days of admission
Clinical outcomes in the bleeding group · at discharge
- Survival at discharge
- 27.4%
- Favorable neurological outcome at discharge
- 14.1%
Original publication
Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a secondary analysis of the SAVE-J II study. Ann Intensive Care. Published 28 January 2024. doi:10.
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