Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study
Authors' conclusion
Compared to general population, incidence of cancer is increased in 1-year sepsis survivors.
Study context
- Population
- Adult ICU patients with sepsis, Swedish Intensive care registry, 2005–2017, surviving 1 year75,427 person years
- Participants
- 18,550 patients
- Exposure
- 1-year sepsis survivors vs general population
- 1-year sepsis survivorsn = 18,550
- Outcome
- Standardized incidence rate ratio (SIR) of new cancer vs general population
Main finding
As reported in the abstract
New cancer, incidence vs general population (NORDCAN) · whole FU
1-year survivors
8.8%
1625 events
Standardized incidence ratio (95% CI)
Men
1.31(1.23–1.40)
Women
1.74(1.61–1.88)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Death during FU | 1-year survivors 34.3% |
Sensitivity analyses
- Difference in incidence rates persisted in several sensitivity analyses
Cancer sites
- SIRs highest in cancers of gastrointestinal tract, genital organs and skin
Original publication
Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study. Crit Care. Published 29 September 2023. doi:10.
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