Perioperative medicine & outcomes
Risk of Venous Thromboembolism After Total Knee Arthroplasty in Patients with Obstructive Sleep Apnea: Results from a National Cohort
Main finding · DVT/PEResult — go to the resultOdds ratio 1.19 CI 1.1–1.3Authors' conclusion
In this study encompassing a nationally representative sample of TKA patients, OSA was associated with increased incidence of VTE at 1 month postoperatively, an association that persisted after the generation of matched cohorts.
Study context
- Population
- US adults undergoing total knee arthroplasty (TKA), January 1, 2013 to January 1, 2023underwent TKA
- Participants
- 197,460 adults
- Exposure
- Preexisting obstructive sleep apnea (OSA) vs no OSA
- OSAn = 27,976
- No OSAn = 150,830reference
- Outcome
- Venous thromboembolism (VTE):
- DVT
- PE
- Follow-up
- 1 month postoperatively
Methodological details1:1 propensity score-matched, national database (TriNetX)
- 1:1 propensity score-matched
- National database (TriNetX)
Main finding
DVT/PE · 1 month
Odds ratio
1.19
CI 1.1–1.3
P < 0.001
OSA vs No OSA
OR 1.19 (CI 1.1–1.3); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| DVT · 1 monthPropensity score matched cohorts | 1.11 (1.0–1.2) | P = 0.030 | |
| PE · 1 monthPropensity score matched cohorts | 1.41 (1.2–1.6) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Unmatched analysis: Deep vein thrombosis (DVT)/pulmonary embolism (PE), cerebrovascular accident (CVA), myocardial infarction (MI), DVT and PE · 1 month
- OSA significantly associated with primary and all secondary outcomes in the initial analysis
Original publication
Risk of Venous Thromboembolism After Total Knee Arthroplasty in Patients with Obstructive Sleep Apnea: Results from a National Cohort. Anesth Analg. Published 15 August 2025. doi:10.
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