Safety and recovery profile of patients after inhalational anaesthesia versus target-controlled or manual total intravenous anaesthesia: a systematic review and meta-analysis of randomised controlled trials
Pooled result · ClassIntra grade 3-4 adverse eventsResult — go to the resultRelative risk 1.00 95% CI 0.88–1.12Authors' conclusion
TIVA and IA are comparably safe, with TIVA reducing PONV and agitation, whereas IA offers faster recovery and lower costs.
Study context
- Population
- Patients undergoing GA in RCTs comparing total intravenous anaesthesia (TIVA) and inhalational anaesthesia (IA)385 RCTs
- Comparison
- TIVA vs IA
- Outcome
- ClassIntra grade 3-4 adverse events
Methodological detailssubgroup analyses
- Subgroup analyses
Pooled result
As reported in the abstract
Relative risk
1.00
95% CI 0.88–1.12
P = 0.97
TIVA vs IA
RR 1.00 (95% CI 0.88–1.12); P = 0.97
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| ClassIntra grade 3-4 adverse events, TCI vs manual infusion (subgroup)TCI vs IA | 0.89 (0.66–1.21) | P = 0.46 | |
| ClassIntra grade 3-4 adverse events, TCI vs manual infusion (subgroup)Manual infusion vs IA | 1.03 (0.90–1.17) | P = 0.70 | |
| 0.512Relative risk (log scale) |
Recovery times and costs
- IA favoured
Postoperative nausea and vomiting (PONV) and agitation on emergence
- TIVA favoured
Other outcomes
- No statistical difference
Original publication
Safety and recovery profile of patients after inhalational anaesthesia versus target-controlled or manual total intravenous anaesthesia: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. Published 11 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →