Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study
Authors' conclusion
In this cohort, 76.4% of ICU patients with candidemia were screened for SL and at least one SL was diagnosed in 21.8%. The severity at ICU admission and duration of positive blood cultures were identified as independent risk factors for SL, whereas age and Candida glabrata infection were protective.
Study context
- Population
- Adult intensive care unit (ICU) patients hospitalized for candidemia, 16 French ICUs, 01–2015 to 01–2023376 screened for secondary localization (SL)
- Participants
- 492 patients
- Exposure
- Patients with vs without secondary localization during candidemia
- SLn = 82
- Outcome
- Prevalence of and risk factors for SL
Methodological detailsmulticentre, competing risk analysis
- Multicentre
- Competing risk analysis
Main finding
As reported in the abstract
Prevalence of SL and screening
SL
21.8%
82
- Screened for SL
- 376 (76.4%)
Observational data: associations, not effects.
Further findings
Risk factors for SL (competing risk analysis)
| sdHR (95% CI) | P value | ||
|---|---|---|---|
| SAPSII scoreIndependent risk factor | 1.01 (1.00–1.02) | P = 0.031 | |
| Duration of positive blood culturesIndependent risk factor | 1.05 (1.02–1.08) | P = 0.003 | |
| AgeProtective factor | 0.98 (0.97–1.00) | P = 0.016 | |
| Candida glabrata infectionProtective factor | 0.38 (0.15–0.99) | P = 0.048 | |
| 0.10.31310Subdistribution hazard ratio (log scale) |
Duration of antifungal treatment
P < 0.001
Antifungal escalation
P = 0.002
Original publication
Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study. Crit Care. Published 5 July 2025. doi:10.
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